Higher-order co-mutation interactions in mitochondrial genomes

Abstract Pair-wise co-mutation networks of the mitochondrial genome have already provided ample evidences about roles genetic interactions in manifestation phenotype under altered environmental conditions. Here, we present a method to construct and analyze higher-order interactions, namely, three-uniform hypergraphs for different altitude populations decipher role co-mutating variable sites beyond pair-wise interactions. We considered human DNA residing at altitudes with respect Tibet Asia as case study. found that 50% gene triangles, two positions were occupied by coding genes, which suggested genes are dominantly involved forming hyperedges. Based on weights identified altitude-specific such as, low-altitude ATP6 ND mid-altitude CO1 high-altitude ATP6, CO1, CYB genes. This framework hypergraph serves an avenue future investigation nuclear genomes context phenotypic association disorders